FOXBOROUGH, Mass. -- Buffalo took advantage of sloppy, Tom Brady-less New England to hand the Patriots their first home shutout at Gillette Stadium, winning 16-0 Sunday.It was the first loss of the season for New England (3-1), which was playing its final game before Brady returns from his four-game Deflategate suspension. The Patriots, who moved into Gillette Stadium in 2002, were last blanked at home 6-0 by the New York Jets in 1993 at Foxboro Stadium.Tyrod Taylor connected with LeSean McCoy for a 7-yard touchdown pass in the first quarter, Dan Carpenter added three field goals for Buffalo (2-2).It was Buffalos second win in its last 16 visits to Foxborough. Including his tenure with the New York Jets, it gave Bills coach Rex Ryan his first regular-season road victory over Bill Belichick in eight tries. The last Bills shutout win away From Orchard Park was 23-0 over Washington in a Buffalo home game at Toronto on Oct. 30, 2011.After struggling to maintain drives and finding a run-pass balance, Taylor was spot-on Sunday. He finished 27 for 39 for 246 yards, and directed a unit that was 7 for 15 on third downs. The Bills had been 10 of 36 combined in the first three games.Buffalos defense also carried over its dominant effort from its 33-18 win over Arizona, sacking rookie Jacoby Brissett three times.Brissett made his second consecutive start in place of Jimmy Garoppolo (sore right shoulder). But Brissett, playing a week after injuring his right thumb, struggled to find the command he had in leading the Patriots to a 27-0 win over the Texans. New England finished 1 for 12 on third downs and managed just 277 total yards. The Patriots drove into Buffalo territory only four times, with three of those drives ending in a lost fumble by Brissett, a missed field goal, and a turnover on downs.Nothing was good enough, Belichick said. At any position, at any phase of the game. It just wasnt good enough.After managing to reach the red zone with four drives in their first three games, the Bills did it on their first two series Sunday.Their first possession, a 12-play, 65-yard drive, ended in Taylors touchdown strike to McCoy. The second stretched 52 yards over 10 plays and was capped by the first of two first-half field goals by Dan Carpenter.QUOTABLE:Ryan on getting a regular-season win in Foxborough: God, it feels good to finally win here. ...Its satisfying. But lets face it: They had a player out.Patriots WR Julian Edelman on that missing player: Anytime one of your best players isnt there, theres something missing. We handled a lot of it well. Today we just didnt. The Bills outplayed us, so thats that.PREGAME SCUFFLE: Several punches were thrown when a shoving match erupted near the sideline about an hour before kickoff. The altercation appeared to begin when Brissett was jogging along the field and was shoved by Bills safety Robert Blanton. Brissett didnt stop, and New England rookie receiver Malcolm Mitchell retaliated by shoving Blanton. Blanton responded by punching Mitchell in the chest and head-butting him, which led to several other players and assistant coaches getting involved. Later, Bills safety Aaron Williams shoved a Patriots assistant coach attempting to separate the players. As the scuffles began to dissipate, Buffalo cornerback Nickell Robey-Coleman landed a punch on Blantons facemask.FIRST DOWN EFFICIENCY: The Bills matched a season high for first downs with 16 in the first half alone. Buffalo had 16 in each of its past two games after opening the season with 11 in a 13-7 loss at Baltimore. Taylor opened by hitting 14 of his first 17 attempts for 138 yards and a touchdown before closing the half 17 of 22 for 165 yards. That topped the 119 yards passing he had in last weeks 33-18 win over Arizona.SLOW GOING: The Patriots offense was anemic in the opening quarter, failing to get a first down while managing 20 total yards. It was the first time the Patriots went without a first-quarter first down since Week 8 of 2011 against Pittsburgh. Bills safety Aaron Williams said the win was still satisfying even with Brady out.Were probably going to hear the excuses that (Brissett) was a third-string quarterback. Garoppolo was out and Tom didnt (play) ... Its a game man. They get paid just like we do. They got to prepare just like we do.FIRST CATCH: TE Rob Gronkowski, who played sparingly in his season debut last week, caught his first pass of the season, an 11-yard reception in the fourth quarter.INJURIES: Patriots DT Vincent Valentine left in the third quarter with a back injury. Bills CB Corey White was escorted to the locker room in the fourth quarter and placed in the concussion protocol after being shaken up while covering punt.---AP NFL websites: http://pro32.ap.org and http://twitter.com/AP-NFLShawn Kelley Rangers Jersey . Brandon Morrow allowed five runs on six hits over three innings. He struck out two, walked one and hit a batter. Edwin Encarnacion had a two-out, bases loaded two-RBI double in the third inning. Kenny Rogers Jersey . -- If Henry Burris has his way, he will be the starting quarterback to lead the Hamilton Tiger-Cats back to the Grey Cup next year. https://www.cheaprangersbaseball.com/1332h-carlos-beltran-jersey-rangers.html . - Derek Wolfe says hes finally healthy after suffering a seizure in November that doctors now believe was related to the spinal cord injury he suffered in the preseason. Kyle Bird Jersey . Scott Kazmir allowed four hits in seven shutout innings, Michael Brantley hit a two-run homer in a three-run first inning and the Indians maintained their hold on an AL wild-card spot with a 4-1 win over the Houston Astros on Saturday night. Jason Grilli Rangers Jersey . -- Playing time has been limited for Maxim Tissot this season, so the Montreal Impact defender made the most of his first scoring opportunity on Saturday. LOUISVILLE, Ky. -- Baskets fell when Louisville needed them, but coach Rick Pitino was more pleased by the defense that created those timely opportunities against Purdues fierce rally.Nearly every Cardinal had a hand in the effort, literally and figuratively, to gut out a tough win.Ray Spalding and Mangok Mathiang each scored 11 points and Donovan Mitchell had critical points and rebounds down the stretch to help No. 14 Louisville hold off No. 15 Purdue 71-64 on Wednesday night in the ACC/Big Ten Challenge.Seeking a rebound from their second-half collapse against Baylor in the Battle 4 Atlantis championship when they lost a 22-point lead, the Cardinals held Purdue to a season-low 36 percent shooting but needed key baskets in the final minutes as the Boilermakers cut a 51-33 deficit to four with 14.4 seconds left.Ryan McMahons 3-pointer with 4 minutes remaining helped along with Mathiangs layup with 2:30 left, but Mitchells late scoring, including a jumper then two free throws with 2 seconds left, helped the Cardinals (6-1) escape with their first win over Purdue since 1996. Mitchell finished with five rebounds with the final one setting up his game-clinching free throws.Louisvilles 32-18 advantage in the paint was big with Anas Mahmoud adding nine points. He fouled out with 1:41 left. Spalding had nine rebounds and Mathiang eight as the Cardinals edged the Boilermakers 36-34 on the boards.I definitely think our length and athleticism bothered them, Spalding said after recording season highs in points and rebounds. They were really big guys, really good basketball players. ... We just had to use our quickness against them.Caleb Swanigan had 14 second-half points and 11 rebounds and P.J. Thompson scored 13, but the Boilermakers (5-2) had their four-game winning streak stopped along with a conference-record seven-game winning streak in the Challenge. Swanigans scoreless first half symbolized Louisvilles effectiveness that carried over into getting the needed late stops as Purdue cut into its lead.We trapped. We fronted. We went affter it really hard, Pitino said.dddddddddddd The guys really focused on the game plan. We knew how tough they are and they wanted to stay in the game, but Ray is the length guy. When Ray pressures the ball up top, they cant get the high-low.THE BIG PICTUREPurdue: The Boilermakers entered ranked seventh in assists at nearly 20 per game but had just five in the first half and finished with 13. A perimeter game that started just 4 of 12 in the first half improved to 6 of 11 in the second en route to finishing above 43 percent for the fifth straight game. Their 17 turnovers led to just 11 Louisville points, but coach Matt Painter wasnt happy with the mistakes.Just a lack of concentration with those 10 (first half) turnovers, he said. We have experienced players turning the basketball over. We have to do a better job of concentrating and making easy plays and getting good shots in the half court.Louisville: The Cardinals pushed the tempo from the start and their defense forced 10 first-half turnovers against Purdues height. They forced 17 turnovers overall and shot 48 percent. ... Pitino used his bench early, playing 12 in the first half alone. That depth was really important because of the style we play, graduate transfer guard Tony Hicks said. If were able to play 12 guys, that just means were able to work harder and thats important in speeding teams up and turning them over on the defensive end.POLL IMPLICATIONSLouisville figures to remain the same depending on what happens at Grand Canyon. Purdue shouldnt drop much with a loss to the No. 14 team.UP NEXTPurdue: The Boilermakers will face their second straight Kentucky school when they host Morehead State on Saturday in their first meeting since 1985.Louisville: The Cardinals travel Phoenix to face Dan Majerle-coached Grand Canyon on Saturday night. They won last years inaugural meeting 111-63.---More AP College Basketball: www.collegebasketball.ap.org ' ' '